The analysis of the systematic factors of the flexible and interconnected development of specific historical examples provided by small-scale industrial firm agglomerations in advanced and developing countries, leads to useful conclusions over the endogenous development of similar local industrial agglomerations at any place, just like in the case of the small-scale engineering-metallic products agglomerations sectors in Eleona, in Attica. The entrepreneurial activity constitutes in the development process substantial element but the implementation of a sectorally and spatial specialized, active industrial policy remains the basics pre-condition for the transformation of the local industrial agglomeration into a dynamic industrial cluster able to complete in the global markets on a collective efficiency basis.